Genomic Hypomethylation in the Human Germline Associates with Selective Structural Mutability in the Human Genome

The hotspots of structural polymorphisms and structural mutability in the human genome remain to be explained mechanistically. We examine associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination (NAHR) mediated by low-copy repeats (LCRs). Comb...

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Detalles Bibliográficos
Autores principales: Li, Jian, Harris, R. Alan, Cheung, Sau Wai, Coarfa, Cristian, Jeong, Mira, Goodell, Margaret A., White, Lisa D., Patel, Ankita, Kang, Sung-Hae, Shaw, Chad, Chinault, A. Craig, Gambin, Tomasz, Gambin, Anna, Lupski, James R., Milosavljevic, Aleksandar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355074/
https://www.ncbi.nlm.nih.gov/pubmed/22615578
http://dx.doi.org/10.1371/journal.pgen.1002692

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355074/
https://www.ncbi.nlm.nih.gov/pubmed/22615578
http://dx.doi.org/10.1371/journal.pgen.1002692

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