Cargando…
Genomic Hypomethylation in the Human Germline Associates with Selective Structural Mutability in the Human Genome
The hotspots of structural polymorphisms and structural mutability in the human genome remain to be explained mechanistically. We examine associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination (NAHR) mediated by low-copy repeats (LCRs). Comb...
Autores principales: | Li, Jian, Harris, R. Alan, Cheung, Sau Wai, Coarfa, Cristian, Jeong, Mira, Goodell, Margaret A., White, Lisa D., Patel, Ankita, Kang, Sung-Hae, Shaw, Chad, Chinault, A. Craig, Gambin, Tomasz, Gambin, Anna, Lupski, James R., Milosavljevic, Aleksandar |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355074/ https://www.ncbi.nlm.nih.gov/pubmed/22615578 http://dx.doi.org/10.1371/journal.pgen.1002692 |
Ejemplares similares
-
Confounding by Repetitive Elements and CpG Islands Does Not Explain the Association between Hypomethylation and Genomic Instability
por: Harris, R. Alan, et al.
Publicado: (2013) -
Comment on “Genomic Hypomethylation in the Human Germline Associates with Selective Structural Mutability in the Human Genome”
por: Watson, Corey T., et al.
Publicado: (2013) -
Analysis of interactions between the epigenome and structural mutability of the genome using Genboree workbench tools
por: Coarfa, Cristian, et al.
Publicado: (2014) -
Human endogenous retroviral elements promote genome instability via non-allelic homologous recombination
por: Campbell, Ian M, et al.
Publicado: (2014) -
NAHR-mediated copy-number variants in a clinical population: Mechanistic insights into both genomic disorders and Mendelizing traits
por: Dittwald, Piotr, et al.
Publicado: (2013)