Cargando…

Deletion of PTH Rescues Skeletal Abnormalities and High Osteopontin Levels in Klotho (−/−) Mice

Maintenance of normal mineral ion homeostasis is crucial for many biological activities, including proper mineralization of the skeleton. Parathyroid hormone (PTH), Klotho, and FGF23 have been shown to act as key regulators of serum calcium and phosphate homeostasis through a complex feedback mechan...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yuan, Quan, Sato, Tadatoshi, Densmore, Michael, Saito, Hiroaki, Schüler, Christiane, Erben, Reinhold G., Lanske, Beate
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355080/ https://www.ncbi.nlm.nih.gov/pubmed/22615584 http://dx.doi.org/10.1371/journal.pgen.1002726

Ejemplares similares

Parathyroid-Specific Deletion of Klotho Unravels a Novel Calcineurin-Dependent FGF23 Signaling Pathway That Regulates PTH Secretion
por: Olauson, Hannes, et al.
Publicado: (2013)

Klotho Lacks a Vitamin D Independent Physiological Role in Glucose Homeostasis, Bone Turnover, and Steady-State PTH Secretion In Vivo
por: Anour, René, et al.
Publicado: (2012)

Editorial: Endocrine and Paracrine Role of FGF23 and Klotho in Health and Disease
por: Erben, Reinhold G.
Publicado: (2019)

α-Klotho's effects on mineral homeostasis are fibroblast growth factor-23 dependent
por: Erben, Reinhold G.
Publicado: (2018)

Molecular interactions of FGF23 and PTH in phosphate regulation
por: Lanske, Beate, et al.
Publicado: (2014)

FGF23 neutralization improves bone quality and osseointegration of titanium implants in chronic kidney disease mice
por: Sun, Ningyuan, et al.
Publicado: (2015)

Genetic Evidence of Serum Phosphate-Independent Functions of FGF-23 on Bone
por: Sitara, Despina, et al.
Publicado: (2008)

PTH, FGF-23, Klotho and Vitamin D as regulators of calcium and phosphorus: Genetics, epigenetics and beyond
por: Portales-Castillo, Ignacio, et al.
Publicado: (2022)

Role of Gut Microbiota in the Skeletal Response to PTH
por: Pacifici, Roberto
Publicado: (2020)

OR03-2 Different Effects of Abaloparatide and h-PTH(1-34) on Osteoclastogenesis and Bone Resorption
por: Arlt, Heike, et al.
Publicado: (2019)

Decreased expression of calcium-sensing receptor and parafibromin in secondary hyperparathyroidism with an abnormal whole PTH/intact PTH ratio
por: Yamada, Shunsuke, et al.
Publicado: (2013)

Administration of α-Klotho Does Not Rescue Renal Anemia in Mice
por: Park, Min Young, et al.
Publicado: (2022)

Intra-articularly injected mesenchymal stem cells promote cartilage regeneration, but do not permanently engraft in distant organs
por: Satué, María, et al.
Publicado: (2019)

FGF23 acts directly on renal proximal tubules to induce phosphaturia through activation of the ERK1/2–SGK1 signaling pathway
por: Andrukhova, Olena, et al.
Publicado: (2012)

Skeletal muscle as a regulator of the longevity protein, Klotho
por: Avin, Keith G., et al.
Publicado: (2014)

Genetic Ablation of Fgf23 or Klotho Does not Modulate Experimental Heart Hypertrophy Induced by Pressure Overload
por: Slavic, Svetlana, et al.
Publicado: (2017)

Augmented Fibroblast Growth Factor-23 Secretion in Bone Locally Contributes to Impaired Bone Mineralization in Chronic Kidney Disease in Mice
por: Andrukhova, Olena, et al.
Publicado: (2018)

Sex‐Specific Differences in G(s)α‐Mediated Signaling Downstream of PTH1R Activation by Abaloparatide in Bone
por: Swami, Srilatha, et al.
Publicado: (2022)

2q37 Deletions in Patients With an Albright Hereditary Osteodystrophy Phenotype and PTH Resistance
por: Elli, Francesca Marta, et al.
Publicado: (2019)

Targeted Pth4-expressing cell ablation impairs skeletal mineralization in zebrafish
por: Suarez-Bregua, Paula, et al.
Publicado: (2017)

Kindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice
por: Fu, Xuekun, et al.
Publicado: (2020)

Conditional Knockdown of Osteopontin Inhibits Breast Cancer Skeletal Metastasis
por: Kovacheva, Marineta, et al.
Publicado: (2019)

Optimization of PTH/PTHrP Hybrid Peptides to Derive a Long‐Acting PTH Analog (LA‐PTH)
por: Noda, Hiroshi, et al.
Publicado: (2020)

In Vitro Effects of PTH (1-84) on Human Skeletal Muscle-Derived Satellite Cells
por: Romagnoli, Cecilia, et al.
Publicado: (2023)

Age dependent increase in the levels of osteopontin inhibits skeletal muscle regeneration
por: Paliwal, Preeti, et al.
Publicado: (2012)

FGF-23–Klotho signaling stimulates proliferation and prevents vitamin D–induced apoptosis
por: Medici, Damian, et al.
Publicado: (2008)

Comparable Initial Engagement of Intracellular Signaling Pathways by Parathyroid Hormone Receptor Ligands Teriparatide, Abaloparatide, and Long‐Acting PTH
por: Sato, Tadatoshi, et al.
Publicado: (2021)

Skeletal diseases caused by mutations in PTH1R show aberrant differentiation of skeletal progenitors due to dysregulation of DEPTOR
por: Csukasi, Fabiana, et al.
Publicado: (2023)

A stalled-ribosome rescue factor Pth3 is required for mitochondrial translation against antibiotics in Saccharomyces cerevisiae
por: Hoshino, Soichiro, et al.
Publicado: (2021)

Klotho in Osx(+)-mesenchymal progenitors exerts pro-osteogenic and anti-inflammatory effects during mandibular alveolar bone formation and repair
por: Fan, Yi, et al.
Publicado: (2022)

FGF23 regulates renal sodium handling and blood pressure
por: Andrukhova, Olena, et al.
Publicado: (2014)

Partial Genetic Deletion of Klotho Aggravates Cardiac Calcium Mishandling in Acute Kidney Injury
por: González-Lafuente, Laura, et al.
Publicado: (2023)

Skeletal Muscle Expression of the Adhesion-GPCR CD97: CD97 Deletion Induces an Abnormal Structure of the Sarcoplasmatic Reticulum but Does Not Impair Skeletal Muscle Function
por: Zyryanova, Tatiana, et al.
Publicado: (2014)

The biphasic and age-dependent impact of klotho on hallmarks of aging and skeletal muscle function
por: Clemens, Zachary, et al.
Publicado: (2021)

Abnormally decreased renal Klotho is linked to endoplasmic reticulum-associated degradation in mice
por: Li, ShaSha, et al.
Publicado: (2022)

Inverse correlation of intact PTH, oxidized PTH as well as non-oxidized PTH with 25-hydroxyvitamin D3 in kidney transplant recipients
por: Zuo, Jiao, et al.
Publicado: (2023)

Deletion of osteopontin or bone sialoprotein induces opposite bone responses to mechanical stimulation in mice
por: Maalouf, M., et al.
Publicado: (2022)

High sodium reduced the expression of PTH1R and Klotho by inhibiting 1,25(OH)(2)D(3) synthesis in cultured proximal tubule epithelial cells
por: Gu, Jie, et al.
Publicado: (2022)

Osteopontin is linked with AKT, FoxO1, and myostatin in skeletal muscle cells
por: Nghiem, Peter P., et al.
Publicado: (2017)

Shank3 deletion in PV neurons is associated with abnormal behaviors and neuronal functions that are rescued by increasing GABAergic signaling
por: Pagano, Jessica, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ma7bjb93qbj9bcspu2v359quf7