ATG5 Is Essential for ATG8-Dependent Autophagy and Mitochondrial Homeostasis in Leishmania major

Macroautophagy has been shown to be important for the cellular remodelling required for Leishmania differentiation. We now demonstrate that L. major contains a functional ATG12-ATG5 conjugation system, which is required for ATG8-dependent autophagosome formation. Nascent autophagosomes were found co...

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Detalles Bibliográficos
Autores principales: Williams, Roderick A. M., Smith, Terry K., Cull, Benjamin, Mottram, Jeremy C., Coombs, Graham H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355087/
https://www.ncbi.nlm.nih.gov/pubmed/22615560
http://dx.doi.org/10.1371/journal.ppat.1002695

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355087/
https://www.ncbi.nlm.nih.gov/pubmed/22615560
http://dx.doi.org/10.1371/journal.ppat.1002695

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