The Electrically Silent Kv6.4 Subunit Confers Hyperpolarized Gating Charge Movement in Kv2.1/Kv6.4 Heterotetrameric Channels

The voltage-gated K(+) (Kv) channel subunit Kv6.4 does not form functional homotetrameric channels but co-assembles with Kv2.1 to form functional Kv2.1/Kv6.4 heterotetrameric channels. Compared to Kv2.1 homotetramers, Kv6.4 exerts a ∼40 mV hyperpolarizing shift in the voltage-dependence of Kv2.1/Kv6...

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Detalles Bibliográficos
Autores principales: Bocksteins, Elke, Labro, Alain J., Snyders, Dirk J., Mohapatra, Durga P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355112/
https://www.ncbi.nlm.nih.gov/pubmed/22615922
http://dx.doi.org/10.1371/journal.pone.0037143

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355112/
https://www.ncbi.nlm.nih.gov/pubmed/22615922
http://dx.doi.org/10.1371/journal.pone.0037143

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