Pretubulysin: From Hypothetical Biosynthetic Intermediate to Potential Lead in Tumor Therapy

Pretubulysin is a natural product that is found in strains of myxobacteria in only minute amounts. It represents the first enzyme-free intermediate in the biosynthesis of tubulysins and undergoes post-assembly acylation and oxidation reactions. Pretubulysin inhibits the growth of cultured mammalian...

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Detalles Bibliográficos
Autores principales: Herrmann, Jennifer, Elnakady, Yasser A., Wiedmann, Romina M., Ullrich, Angelika, Rohde, Manfred, Kazmaier, Uli, Vollmar, Angelika M., Müller, Rolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355125/
https://www.ncbi.nlm.nih.gov/pubmed/22616003
http://dx.doi.org/10.1371/journal.pone.0037416

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355125/
https://www.ncbi.nlm.nih.gov/pubmed/22616003
http://dx.doi.org/10.1371/journal.pone.0037416

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