The Activation of DNA Damage Detection and Repair Responses in Cleavage-Stage Rat Embryos by a Damaged Paternal Genome

Male germ cell DNA damage, after exposure to radiation, exogenous chemicals, or chemotherapeutic agents, is a major cause of male infertility. DNA-damaged spermatozoa can fertilize oocytes; this is of concern because there is limited information on the capacity of early embryos to repair a damaged m...

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Detalles Bibliográficos
Autores principales: Grenier, Lisanne, Robaire, Bernard, Hales, Barbara F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Reproductive and Developmental Toxicology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355317/
https://www.ncbi.nlm.nih.gov/pubmed/22454429
http://dx.doi.org/10.1093/toxsci/kfs120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355317/
https://www.ncbi.nlm.nih.gov/pubmed/22454429
http://dx.doi.org/10.1093/toxsci/kfs120

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