Targets and Intracellular Signaling Mechanisms for Deoxynivalenol-Induced Ribosomal RNA Cleavage

The trichothecene mycotoxin deoxynivalenol (DON), a known translational inhibitor, induces ribosomal RNA (rRNA) cleavage. Here, we characterized this process relative to (1) specific 18S and 28S ribosomal RNA cleavage sites and (2) identity of specific upstream signaling elements in this pathway. Ca...

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Detalles Bibliográficos
Autores principales: He, Kaiyu, Zhou, Hui-Ren, Pestka, James J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Immunotoxicology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355321/
https://www.ncbi.nlm.nih.gov/pubmed/22491426
http://dx.doi.org/10.1093/toxsci/kfs134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355321/
https://www.ncbi.nlm.nih.gov/pubmed/22491426
http://dx.doi.org/10.1093/toxsci/kfs134

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