Cargando…

Targets and Intracellular Signaling Mechanisms for Deoxynivalenol-Induced Ribosomal RNA Cleavage

The trichothecene mycotoxin deoxynivalenol (DON), a known translational inhibitor, induces ribosomal RNA (rRNA) cleavage. Here, we characterized this process relative to (1) specific 18S and 28S ribosomal RNA cleavage sites and (2) identity of specific upstream signaling elements in this pathway. Ca...

Descripción completa

Detalles Bibliográficos
Autores principales:	He, Kaiyu, Zhou, Hui-Ren, Pestka, James J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Immunotoxicology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355321/ https://www.ncbi.nlm.nih.gov/pubmed/22491426 http://dx.doi.org/10.1093/toxsci/kfs134

Ejemplares similares

Influence of deoxynivalenol-contaminated feed on the immune response of pigs after PRRSV vaccination and infection
por: Pierron, Alix, et al.
Publicado: (2023)

Clozapine Induces an Acute Proinflammatory Response That Is Attenuated by Inhibition of Inflammasome Signaling: Implications for Idiosyncratic Drug-Induced Agranulocytosis
por: Sernoskie, Samantha Christine, et al.
Publicado: (2021)

Electronic cigarette vapour moderately stimulates pro-inflammatory signalling pathways and interleukin-6 production by human monocyte-derived dendritic cells
por: Chen, I-Ling, et al.
Publicado: (2020)

Identification of flucloxacillin-modified hepatocellular proteins: implications in flucloxacillin-induced liver injury
por: Ali, Serat-E, et al.
Publicado: (2023)

Amiodarone Exposure During Modest Inflammation Induces Idiosyncrasy-like Liver Injury in Rats: Role of Tumor Necrosis Factor-alpha
por: Lu, Jingtao, et al.
Publicado: (2012)

Immunological impact of graphene oxide sheets in the abdominal cavity is governed by surface reactivity
por: Rodrigues, Artur Filipe, et al.
Publicado: (2018)

An adverse outcome pathway for immune-mediated and allergic hepatitis: a case study with the NSAID diclofenac
por: Selvaraj, Saravanakumar, et al.
Publicado: (2020)

The GARDpotency Assay for Potency-Associated Subclassification of Chemical Skin Sensitizers—Rationale, Method Development, and Ring Trial Results of Predictive Performance and Reproducibility
por: Gradin, Robin, et al.
Publicado: (2020)

Characterization of the Class I MHC Peptidome Resulting From DNCB Exposure of HaCaT Cells
por: Bailey, Alistair, et al.
Publicado: (2020)

Deciphering Adverse Drug Reactions: In Vitro Priming and Characterization of Vancomycin-Specific T Cells From Healthy Donors Expressing HLA-A*32:01
por: Ogese, Monday O, et al.
Publicado: (2021)

Preliminary nonclinical safety and immunogenicity of an rVSV-ΔG-SARS-CoV-2-S vaccine in mice, hamsters, rabbits and pigs
por: Madar-Balakirski, Noa, et al.
Publicado: (2022)

Mouse innate-like B-1 lymphocytes promote inhaled particle-induced in vitro granuloma formation and inflammation in conjunction with macrophages
por: Hiéronimus, Léa, et al.
Publicado: (2021)

Checkpoint Inhibition Reduces the Threshold for Drug-Specific T-Cell Priming and Increases the Incidence of Sulfasalazine Hypersensitivity
por: Hammond, Sean, et al.
Publicado: (2021)

Non-clinical immunogenicity, biodistribution and toxicology evaluation of a chimpanzee adenovirus-based COVID-19 vaccine in rat and rhesus macaque
por: Dai, Xuedong, et al.
Publicado: (2022)

rVSV-ΔG-SARS-CoV-2-S vaccine: repeated intramuscular (IM) toxicity, local tolerance, immunogenicity and biodistribution study in NZW rabbits
por: Rosner, Amir, et al.
Publicado: (2022)

Electronic cigarette vapor exposure exaggerates the pro-inflammatory response during influenza A viral infection in human distal airway epithelium
por: Schaunaman, Niccolette, et al.
Publicado: (2022)

Increased serum anti-CYP2E1 IgG autoantibody levels may be involved in the pathogenesis of occupational trichloroethylene hypersensitivity syndrome: a case–control study
por: Nakajima, Tamie, et al.
Publicado: (2022)

Quantifying the impact of PFOA exposure on B-cell development and antibody production
por: Taylor, Krystal D, et al.
Publicado: (2023)

Role of miR-24-3p and miR-146a-5p in dendritic cells’ maturation process induced by contact sensitizers
por: Galbiati, Valentina, et al.
Publicado: (2023)

Development of an in chemico high-throughput screening method for the identification of skin sensitization potential
por: Ferreira, Isabel, et al.
Publicado: (2023)

Applicability of the DPRA on mixture testing: challenges and opportunities
por: Marcelis, Quinten, et al.
Publicado: (2023)

Direct Activation of Ribosome-Associated Double-Stranded RNA-Dependent Protein Kinase (PKR) by Deoxynivalenol, Anisomycin and Ricin: A New Model for Ribotoxic Stress Response Induction
por: Zhou, Hui-Ren, et al.
Publicado: (2014)

Deoxynivalenol-Induced Proinflammatory Gene Expression: Mechanisms and Pathological Sequelae
por: Pestka, James J.
Publicado: (2010)

Commentary. Looking back
por: Eisen, Herman N.
Publicado: (1989)

Murine Anorectic Response to Deoxynivalenol (Vomitoxin) Is Sex-Dependent
por: Clark, Erica S., et al.
Publicado: (2015)

Sex Is a Determinant for Deoxynivalenol Metabolism and Elimination in the Mouse
por: Pestka, James J., et al.
Publicado: (2017)

Ribosome quality control is a central protection mechanism for yeast exposed to deoxynivalenol and trichothecin
por: Kugler, Karl G., et al.
Publicado: (2016)

Beyond Ribosomal Binding: The Increased Polarity and Aberrant Molecular Interactions of 3-epi-deoxynivalenol
por: Hassan, Yousef I., et al.
Publicado: (2016)

Advances in Deoxynivalenol Toxicity Mechanisms: The Brain as a Target
por: Bonnet, Marion S., et al.
Publicado: (2012)

High Sensitivity of Aged Mice to Deoxynivalenol (Vomitoxin)-Induced Anorexia Corresponds to Elevated Proinflammatory Cytokine and Satiety Hormone Responses
por: Clark, Erica S., et al.
Publicado: (2015)

Correction: Pestka, J.J., et al. Sex Is a Determinant for Deoxynivalenol Metabolism and Elimination in the Mouse. Toxins 2017, 9, 240
por: Pestka, James J., et al.
Publicado: (2019)

Cutting in-line with iron: ribosomal function and non-oxidative RNA cleavage
por: Guth-Metzler, Rebecca, et al.
Publicado: (2020)

Solvent and Water Mediated Structural Variations in Deoxynivalenol and Their Potential Implications on the Disruption of Ribosomal Function
por: Foroud, Nora A., et al.
Publicado: (2016)

Arabidopsis thaliana XRN2 is required for primary cleavage in the pre-ribosomal RNA
por: Zakrzewska-Placzek, Monika, et al.
Publicado: (2010)

A ribosome profiling study of mRNA cleavage by the endonuclease RelE
por: Hwang, Jae-Yeon, et al.
Publicado: (2017)

MicroRNA-directed cleavage of targets: mechanism and experimental approaches
por: Park, June Hyun, et al.
Publicado: (2014)

The Structural Basis for mRNA Recognition and Cleavage by the Ribosome-Dependent Endonuclease RelE
por: Neubauer, Cajetan, et al.
Publicado: (2009)

Cell Death-Associated Ribosomal RNA Cleavage in Postmortem Tissues and Its Forensic Applications
por: Kim, Ji Yeon, et al.
Publicado: (2017)

SARS-CoV-2 NSP1 induces mRNA cleavages on the ribosome
por: Tardivat, Yann, et al.
Publicado: (2023)

Biodegradation of Deoxynivalenol by Nocardioides sp. ZHH-013: 3-keto-Deoxynivalenol and 3-epi-Deoxynivalenol as Intermediate Products
por: Zhang, Honghai, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_276kvt0c7qhe8bj5khoolkfi9p