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Reversed Chloroquine Molecules as a Strategy to Overcome Resistance in Malaria
This short review tells the story of how Reversed Chloroquine drugs (RCQs) were developed. These are hybrid molecules, made by combining the quinoline nucleus from chloroquine (CQ) with moieties which are designed to inhibit efflux via known transporters in the membrane of the digestive vacuole of t...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Bentham Science Publishers
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355467/ https://www.ncbi.nlm.nih.gov/pubmed/22242848 http://dx.doi.org/10.2174/156802612799362968 |