The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508

[Image: see text] CDK9 is the kinase of positive transcription elongation factor b and facilitates the transition of paused RNA polymerase II to processive transcription elongation. CDK9 is a validated target for the treatment of cancer, cardiac hypertrophy, and human immunodeficiency virus. Here we...

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Detalles Bibliográficos
Autores principales: Baumli, Sonja, Hole, Alison J., Noble, Martin E. M., Endicott, Jane A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355656/
https://www.ncbi.nlm.nih.gov/pubmed/22292676
http://dx.doi.org/10.1021/cb2004516

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355656/
https://www.ncbi.nlm.nih.gov/pubmed/22292676
http://dx.doi.org/10.1021/cb2004516

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