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Pathogenic Role of the CRL4 Ubiquitin Ligase in Human Disease
The cullin 4-RING ubiquitin ligase (CRL4) family employs multiple DDB1–CUL4 associated factors substrate receptors to direct the degradation of proteins involved in a wide spectrum of cellular functions. Aberrant expression of the cullin 4A (CUL4A) gene is found in many tumor types, while mutations...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Research Foundation
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355902/ https://www.ncbi.nlm.nih.gov/pubmed/22649780 http://dx.doi.org/10.3389/fonc.2012.00021 |