Cargando…

The Roles of VHL-Dependent Ubiquitination in Signaling and Cancer

The function of tumor suppressor VHL is compromised in the vast majority of clear cell renal cell carcinoma, and its mutations or loss of expression was causal for this disease. pVHL was found to be a substrate recognition subunit of an E3 ubiquitin ligase, and most of the tumor-derived mutations di...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Qing, Yang, Haifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355907/
https://www.ncbi.nlm.nih.gov/pubmed/22649785
http://dx.doi.org/10.3389/fonc.2012.00035