Cargando…

Extracellular Domain N-Glycosylation Controls Human Thrombopoietin Receptor Cell Surface Levels

The thrombopoietin receptor (TpoR) is a type I transmembrane protein that mediates the signaling functions of thrombopoietin (Tpo) in regulating megakaryocyte differentiation, platelet formation, and hematopoietic stem cell renewal. We probed the role of each of the four extracellular domain putativ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Albu, Roxana I., Constantinescu, Stefan N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Research Foundation 2011
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355985/ https://www.ncbi.nlm.nih.gov/pubmed/22649382 http://dx.doi.org/10.3389/fendo.2011.00071

Ejemplares similares

The Thrombopoietin Receptor: Structural Basis of Traffic and Activation by Ligand, Mutations, Agonists, and Mutated Calreticulin
por: Varghese, Leila N., et al.
Publicado: (2017)

Genetic Alterations of the Thrombopoietin/MPL/JAK2 Axis Impacting Megakaryopoiesis
por: Plo, Isabelle, et al.
Publicado: (2017)

Thrombopoietin receptor is required for the oncogenic function of CALR mutants
por: Nivarthi, H, et al.
Publicado: (2016)

Proteolytic Cleavage of the Extracellular Domain Affects Signaling of Parathyroid Hormone 1 Receptor
por: Klenk, Christoph, et al.
Publicado: (2022)

Thrombopoietin Receptor Levels in Tumor Cell Lines and Primary Tumors
por: Erickson-Miller, Connie L., et al.
Publicado: (2010)

Glycine receptor autoantibody binding to the extracellular domain is independent from receptor glycosylation
por: Rauschenberger, Vera, et al.
Publicado: (2023)

In and out: Traffic and dynamics of thrombopoietin receptor
por: Roy, Anita, et al.
Publicado: (2021)

The ratio of exogenous Luteinizing hormone to Follicle stimulating hormone administered for controlled ovarian stimulation is associated with oocytes’ number and competence
por: Albu, Dragos, et al.
Publicado: (2020)

The P2X7 Receptor is an Important Regulator of Extracellular ATP Levels
por: Brandao-Burch, Andrea, et al.
Publicado: (2012)

Thrombopoietin and its receptor in normal and neoplastic hematopoiesis
por: Kaushansky, Kenneth
Publicado: (2016)

Thrombopoietin receptor agonists: ten years later
por: Ghanima, Waleed, et al.
Publicado: (2019)

Effect of Thrombopoietin Receptor Agonist on Pregnant Mice
por: Nakai, Kensaku, et al.
Publicado: (2022)

Role of Thrombopoietin Receptor Agonists in Inherited Thrombocytopenia
por: Bastida, José María, et al.
Publicado: (2021)

The clinical value of glycosylated hemoglobin level in newly diagnosed ketosis-prone type 2 diabetes
por: Min, Rui, et al.
Publicado: (2023)

Impact of estrogen on IgG glycosylation and serum protein glycosylation in a murine model of healthy postmenopause
por: Gupta, Priti, et al.
Publicado: (2023)

Surface Glycosylation Profiles of Urine Extracellular Vesicles
por: Gerlach, Jared Q., et al.
Publicado: (2013)

The thrombopoietin receptor, c-Mpl, is a selective surface marker for human hematopoietic stem cells
por: Ninos, John M, et al.
Publicado: (2006)

Oncogenic CALR mutant C-terminus mediates dual binding to the thrombopoietin receptor triggering complex dimerization and activation
por: Papadopoulos, Nicolas, et al.
Publicado: (2023)

Use of Thrombopoietin Receptor Agonists in Childhood Immune Thrombocytopenia
por: Garzon, Angelica Maria, et al.
Publicado: (2015)

Optimal use of thrombopoietin receptor agonists in immune thrombocytopenia
por: Al-Samkari, Hanny, et al.
Publicado: (2019)

Thrombocytopenia and Procedural Prophylaxis in the Era of Thrombopoietin Receptor Agonists
por: Nilles, Kathy M., et al.
Publicado: (2019)

The thrombopoietin receptor: revisiting the master regulator of platelet production
por: Hitchcock, Ian S., et al.
Publicado: (2021)

Constitutive activation and oncogenicity are mediated by loss of helical structure at the cytosolic boundary of thrombopoietin receptor mutant dimers
por: Defour, Jean-Philippe, et al.
Publicado: (2023)

Association of Glycosylated Hemoglobin A1c Level With Sudden Sensorineural Hearing Loss: A Prospective Study
por: Shen, Ying, et al.
Publicado: (2021)

Glycosylated extracellular mucin domains protect against SARS-CoV-2 infection at the respiratory surface
por: Chatterjee, Maitrayee, et al.
Publicado: (2023)

N-Glycosylation of the Discoidin Domain Receptor Is Required for Axon Regeneration in Caenorhabditis elegans
por: Shimizu, Tatsuhiro, et al.
Publicado: (2019)

Hormonal Regulation of Follicle-Stimulating Hormone Glycosylation in Males
por: Campo, Stella, et al.
Publicado: (2019)

Overproduction of thrombopoietin by BRAFV600E‐mutated mouse hepatocytes and contribution of thrombopoietin to hepatocarcinogenesis
por: Tanaka, Hiroki, et al.
Publicado: (2019)

The Thrombopoietin Receptor, MPL, Is a Therapeutic Target of Opportunity in the MPN
por: Spivak, Jerry L., et al.
Publicado: (2021)

Mechanism of mutant calreticulin-mediated activation of the thrombopoietin receptor in cancers
por: Venkatesan, Arunkumar, et al.
Publicado: (2021)

Thrombopoietin receptor agonist antibody for treating chemotherapy-induced thrombocytopenia
por: Shin, Jiwon, et al.
Publicado: (2023)

Increased plasma levels of thrombopoietin in patients with severe acute pancreatitis
por: Pigozzi, L, et al.
Publicado: (2013)

Serum Thrombopoietin Levels and Its Relationship With Thrombocytopenia in Patients With Cirrhosis
por: Temel, Tuncer, et al.
Publicado: (2014)

Thrombopoietin levels in Quebec platelet disorder—Implications for the mechanism of thrombocytopenia
por: Hayward, C. P. M., et al.
Publicado: (2018)

Thrombopoietin levels increased in patients with severe acute respiratory syndrome
por: Yang, Mo, et al.
Publicado: (2008)

Thrombopoietin: tickling the HSC's fancy
por: Kim, Ah Ram, et al.
Publicado: (2017)

Glycosylation Pattern and in vitro Bioactivity of Reference Follitropin alfa and Biosimilars
por: Riccetti, Laura, et al.
Publicado: (2019)

The Enigmatic N-Terminal Domain of Proglucagon; A Historical Perspective
por: Conlon, J. Michael
Publicado: (2021)

Control of cell surface expression of GABA(A) receptors by a conserved region at the end of the N-terminal extracellular domain of receptor subunits
por: Yuan, Banghao, et al.
Publicado: (2022)

Preclinical Activity of Eltrombopag (SB-497115), an Oral, Nonpeptide Thrombopoietin Receptor Agonist
por: Erickson-Miller, Connie L, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_gt7905kl6hk3n6pm5kfktb2ejg