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Neuroregenerative Mechanisms of Allopregnanolone in Alzheimer’s Disease

The proliferative pool and regenerative potential of neural stem cells diminishes with age, a phenomenon that may be exacerbated in prodromal and mild Alzheimer’s disease (AD) brains. In parallel, the neuroactive progesterone metabolite, allopregnanolone (APα), along with a host of other factors, is...

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Detalles Bibliográficos
Autores principales: Irwin, Ronald W., Wang, Jun Ming, Chen, Shuhua, Brinton, Roberta Diaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356095/
https://www.ncbi.nlm.nih.gov/pubmed/22654847
http://dx.doi.org/10.3389/fendo.2011.00117