Intrinsic, Pro-Apoptotic Effects of IGFBP-3 on Breast Cancer Cells are Reversible: Involvement of PKA, Rho, and Ceramide

We established previously that IGFBP-3 could exert positive or negative effects on cell function depending upon the extracellular matrix composition and by interacting with integrin signaling. To elicit its pro-apoptotic effects IGFBP-3 bound to caveolin-1 and the beta 1 integrin receptor and increa...

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Detalles Bibliográficos
Autores principales: Perks, Claire M., Burrows, Carla, Holly, Jeff M. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2011
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356103/
https://www.ncbi.nlm.nih.gov/pubmed/22654794
http://dx.doi.org/10.3389/fendo.2011.00013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356103/
https://www.ncbi.nlm.nih.gov/pubmed/22654794
http://dx.doi.org/10.3389/fendo.2011.00013

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