Sunitinib Inhibits Cell Proliferation and Alters Steroidogenesis by Down-Regulation of HSD3B2 in Adrenocortical Carcinoma Cells

The multi-tyrosine kinase inhibitor sunitinib is used in the treatment of several solid tumors. Animal experiments pointed to an adrenotoxic effect of sunitinib. Therefore, we evaluated the expression of key targets of sunitinib in human adrenocortical carcinoma (ACC) tumor samples and investigated...

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Detalles Bibliográficos
Autores principales: Kroiss, Matthias, Reuss, Miriam, Kühner, Dorothee, Johanssen, Sarah, Beyer, Melanie, Zink, Martina, Hartmann, Michaela F., Dhir, Vivek, Wudy, Stefan A., Arlt, Wiebke, Sbiera, Silviu, Allolio, Bruno, Fassnacht, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2011
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356136/
https://www.ncbi.nlm.nih.gov/pubmed/22654799
http://dx.doi.org/10.3389/fendo.2011.00027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356136/
https://www.ncbi.nlm.nih.gov/pubmed/22654799
http://dx.doi.org/10.3389/fendo.2011.00027

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