Improving thermal stability and efficacy of BCNU in treating glioma cells using PAA-functionalized graphene oxide

BACKGROUND: 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), a commercial chemotherapeutic drug for treating malignant brain tumors, has poor thermal stability and a short half-life. Immobilization of BCNU on a nanocarrier might increase the thermal stability of BCNU and extend its half-life. METHODS: N...

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Detalles Bibliográficos
Autores principales: Lu, Yu-Jen, Yang, Hung-Wei, Hung, Sheng-Che, Huang, Chiung-Yin, Li, Shin-Ming, Ma, Chen-Chi M, Chen, Pin-Yuan, Tsai, Hong-Chieh, Wei, Kuo-Chen, Chen, Jyh-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2012
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356218/
https://www.ncbi.nlm.nih.gov/pubmed/22619524
http://dx.doi.org/10.2147/IJN.S29376

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356218/
https://www.ncbi.nlm.nih.gov/pubmed/22619524
http://dx.doi.org/10.2147/IJN.S29376

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