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Evidence that an APOE ε4 'double whammy' increases risk for Alzheimer's disease
Temporal lobe epilepsy (TLE) is associated with some of the same neuropathological features as those reported for early stages of typical Alzheimer's disease (AD). The APOE ε4 allele is associated with a gene-dose-dependent increase in AD risk and in the severity of amyloid-β (Aβ) pathology. In...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356233/ https://www.ncbi.nlm.nih.gov/pubmed/22502767 http://dx.doi.org/10.1186/1741-7015-10-36 |