QM/MM MD and Free Energy Simulations of G9a-Like Protein (GLP) and Its Mutants: Understanding the Factors that Determine the Product Specificity

Certain lysine residues on histone tails could be methylated by protein lysine methyltransferases (PKMTs) using S-adenosyl-L-methionine (AdoMet) as the methyl donor. Since the methylation states of the target lysines play a fundamental role in the regulation of chromatin structure and gene expressio...

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Detalles Bibliográficos
Autores principales: Chu, Yuzhuo, Yao, Jianzhuang, Guo, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356298/
https://www.ncbi.nlm.nih.gov/pubmed/22624060
http://dx.doi.org/10.1371/journal.pone.0037674

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356298/
https://www.ncbi.nlm.nih.gov/pubmed/22624060
http://dx.doi.org/10.1371/journal.pone.0037674

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