Concomitant Administration of Different Doses of Simvastatin with Ivabradine Influence on PAI-1 and Heart Rate in Normo- and Hypercholesterolaemic Rats

Ivabradine is a novel heart rate lowering agent that inhibits I(f) ionic current in the sinus node and demonstrates antiischaemic and antianginal activity. The aim of the paper was to investigate the effect its dose-dependent drug-drug interaction with simvastatin inhibitor HMGCo-A has on PAI-1 bloo...

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Detalles Bibliográficos
Autores principales: Owczarek, Jacek, Jasińska-Stroschein, Magdalena, Orszulak-Michalak, Daria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Scientific World Journal 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356763/
https://www.ncbi.nlm.nih.gov/pubmed/22645493
http://dx.doi.org/10.1100/2012/976519

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356763/
https://www.ncbi.nlm.nih.gov/pubmed/22645493
http://dx.doi.org/10.1100/2012/976519

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