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Protein Kinase Cβ Phosphorylates Occludin Regulating Tight Junction Trafficking in Vascular Endothelial Growth Factor–Induced Permeability In Vivo

Vascular endothelial growth factor (VEGF)–induced breakdown of the blood-retinal barrier requires protein kinase C (PKC)β activation. However, the molecular mechanisms related to this process remain poorly understood. In this study, the role of occludin phosphorylation and ubiquitination downstream...

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Detalles Bibliográficos
Autores principales: Murakami, Tomoaki, Frey, Tiffany, Lin, Chengmao, Antonetti, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357276/
https://www.ncbi.nlm.nih.gov/pubmed/22438576
http://dx.doi.org/10.2337/db11-1367