Cargando…

MDA-7/IL-24 Induces Bcl-2 Denitrosylation and Ubiquitin-Degradation Involved in Cancer Cell Apoptosis

MDA-7/IL-24 was involved in the specific cancer apoptosis through suppression of Bcl-2 expression, which is a key apoptosis regulatory protein of the mitochondrial death pathway. However, the underlying mechanisms of this regulation are unclear. We report here that tumor-selective replicating adenov...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tian, Hui, Wang, Jing, Zhang, BaoFu, Di, JieHui, Chen, FeiFei, Li, HuiZhong, Li, LianTao, Pei, DongSheng, Zheng, JunNian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357419/ https://www.ncbi.nlm.nih.gov/pubmed/22629368 http://dx.doi.org/10.1371/journal.pone.0037200

Ejemplares similares

Manipulation of Mitochondrial Plasticity Changes the Metabolic Competition Between “Foe” and “Friend” During Tumor Malignant Transformation
por: Tian, Hui, et al.
Publicado: (2020)

Nitrosative Stress and Human Disease: Therapeutic Potential of Denitrosylation
por: Yoon, Somy, et al.
Publicado: (2021)

S-Denitrosylation: A Crosstalk between Glutathione and Redoxin Systems
por: Chakraborty, Surupa, et al.
Publicado: (2022)

Crystal-facet-dependent denitrosylation: modulation of NO release from S-nitrosothiols by Cu(2)O polymorphs
por: Ghosh, Sourav, et al.
Publicado: (2019)

N-Methyl-D-Aspartate Receptor-Dependent Denitrosylation of Neuronal Nitric Oxide Synthase Increase the Enzyme Activity
por: Qu, Zhong-Wei, et al.
Publicado: (2012)

GluR6-FasL-Trx2 mediates denitrosylation and activation of procaspase-3 in cerebral ischemia/reperfusion in rats
por: Sun, N, et al.
Publicado: (2013)

Complement C1q binding protein regulates T cells’ mitochondrial fitness to affect their survival, proliferation, and anti–tumor immune function
por: Tian, Hui, et al.
Publicado: (2022)

FBX8 degrades GSTP1 through ubiquitination to suppress colorectal cancer progression
por: FeiFei, Wang, et al.
Publicado: (2019)

Ubiquitin Degradation of the AICAR Transformylase/IMP Cyclohydrolase Ade16 Regulates the Sexual Reproduction of Cryptococcus neoformans
por: Han, Liantao, et al.
Publicado: (2023)

Synergistic Effects of Cabozantinib and EGFR-Specific CAR-NK-92 Cells in Renal Cell Carcinoma
por: Zhang, Qing, et al.
Publicado: (2017)

Doa1 targets ubiquitinated substrates for mitochondria-associated degradation
por: Wu, Xi, et al.
Publicado: (2016)

Corrigendum to “Combination Therapy with EpCAM-CAR-NK-92 Cells and Regorafenib against Human Colorectal Cancer Models”
por: Zhang, Qing, et al.
Publicado: (2019)

Combination Therapy with EpCAM-CAR-NK-92 Cells and Regorafenib against Human Colorectal Cancer Models
por: Zhang, Qing, et al.
Publicado: (2018)

Tumour suppressor function of MDA-7/IL-24 in human breast cancer
por: Patani, Neill, et al.
Publicado: (2010)

Lentivirus-mediated MDA7/IL24 expression inhibits the proliferation of hepatocellular carcinoma cells
por: Ma, Chao, et al.
Publicado: (2018)

Proteomic analysis of degradation ubiquitin signaling by ubiquitin occupancy changes responding to 26S proteasome inhibition
por: Hristova, Ventzislava, et al.
Publicado: (2020)

Ubiquitin ligase RNF125 targets PD-L1 for ubiquitination and degradation
por: Wei, Meng, et al.
Publicado: (2022)

Dephosphorylation Targets Bcl-2 for Ubiquitin-dependent Degradation: A Link between the Apoptosome and the Proteasome Pathway
por: Dimmeler, Stefanie, et al.
Publicado: (1999)

MDA-7/IL-24 suppresses human ovarian carcinoma growth in vitro and in vivo
por: Gopalan, Began, et al.
Publicado: (2007)

P22077 inhibits LPS-induced inflammatory response by promoting K48-linked ubiquitination and degradation of TRAF6
por: Zhao, Xi-Bao, et al.
Publicado: (2020)

Insights into the Mechanisms of Action of MDA-7/IL-24: A Ubiquitous Cancer-Suppressing Protein
por: Modi, Jinkal, et al.
Publicado: (2021)

Correction to: Proteomic analysis of degradation ubiquitin signaling by ubiquitin occupancy changes responding to 26S proteasome inhibition
por: Hristova, Ventzislava, et al.
Publicado: (2020)

Basal level of FANCD2 monoubiquitination is required for the maintenance of a sufficient number of licensed-replication origins to fire at a normal rate
por: Panneerselvam, Jayabal, et al.
Publicado: (2014)

Ubiquitination status does not affect Vps34 degradation
por: Tang, Jing, et al.
Publicado: (2019)

Amplification of ACK1 promotes gastric tumorigenesis via ECD-dependent p53 ubiquitination degradation
por: Xu, Song-Hui, et al.
Publicado: (2015)

Suppression of Her2/Neu mammary tumor development in mda-7/IL-24 transgenic mice
por: Li, You-Jun, et al.
Publicado: (2015)

MBD2 Correlates with a Poor Prognosis and Tumor Progression in Renal Cell Carcinoma
por: Li, Liantao, et al.
Publicado: (2020)

SLFL Genes Participate in the Ubiquitination and Degradation Reaction of S-RNase in Self-compatible Peach
por: Chen, Qiuju, et al.
Publicado: (2018)

A novel oncogenic pathway by TLS–CHOP involving repression of MDA-7/IL-24 expression
por: Oikawa, K, et al.
Publicado: (2012)

Combining histone deacetylase inhibitors with MDA-7/IL-24 enhances killing of renal carcinoma cells
por: Hamed, Hossein A, et al.
Publicado: (2013)

The Anti-fibrosis drug Pirfenidone modifies the immunosuppressive tumor microenvironment and prevents the progression of renal cell carcinoma by inhibiting tumor autocrine TGF-β
por: Wang, Gang, et al.
Publicado: (2022)

Rab21 Protein Is Degraded by Both the Ubiquitin-Proteasome Pathway and the Autophagy-Lysosome Pathway
por: Liu, Pinduo, et al.
Publicado: (2022)

Cullin 3(SPOP) ubiquitin E3 ligase promotes the poly-ubiquitination and degradation of HDAC6
por: Tan, Yuyong, et al.
Publicado: (2017)

TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity
por: Lang, Xueting, et al.
Publicado: (2017)

MDA-7/IL-24 functions as a tumor suppressor gene in vivo in transgenic mouse models of breast cancer
por: Menezes, Mitchell E., et al.
Publicado: (2015)

Prostate transglutaminase (TGase-4) antagonizes the anti-tumour action of MDA-7/IL-24 in prostate cancer
por: Ablin, Richard J, et al.
Publicado: (2011)

Mechanism of internalization of MDA-7/IL-24 protein and its cognate receptors following ligand-receptor docking
por: Pradhan, Anjan K., et al.
Publicado: (2019)

Oncolytic adenovirus-mediated mda-7/IL-24 expression suppresses osteosarcoma growth and enhances sensitivity to doxorubicin
por: Liu, Zongming, et al.
Publicado: (2021)

Double-hit lymphoma (rearrangements of MYC, BCL-2) during pregnancy: A case report
por: Xie, Fan, et al.
Publicado: (2021)

Heterochromatin and RNAi regulate centromeres by protecting CENP-A from ubiquitin-mediated degradation
por: Yang, Jinpu, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_mbk0v72tbbsuf68vpkoo9lbtnn