Penicillamine Increases Free Copper and Enhances Oxidative Stress in the Brain of Toxic Milk Mice

Wilson disease (WD) is characterized by the accumulation of copper arising from a mutation in the ATP7B gene. Penicillamine (PA) makes 10–50% of the patients with neurologic symptoms neurologically worse at the early stage of administration. The aim of this study was to determine how the copper meta...

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Detalles Bibliográficos
Autores principales: Chen, Ding-Bang, Feng, Li, Lin, Xiao-Pu, Zhang, Wei, Li, Fu-Rong, Liang, Xiu-Ling, Li, Xun-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357430/
https://www.ncbi.nlm.nih.gov/pubmed/22629446
http://dx.doi.org/10.1371/journal.pone.0037709

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357430/
https://www.ncbi.nlm.nih.gov/pubmed/22629446
http://dx.doi.org/10.1371/journal.pone.0037709

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