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Penicillamine Increases Free Copper and Enhances Oxidative Stress in the Brain of Toxic Milk Mice
Wilson disease (WD) is characterized by the accumulation of copper arising from a mutation in the ATP7B gene. Penicillamine (PA) makes 10–50% of the patients with neurologic symptoms neurologically worse at the early stage of administration. The aim of this study was to determine how the copper meta...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357430/ https://www.ncbi.nlm.nih.gov/pubmed/22629446 http://dx.doi.org/10.1371/journal.pone.0037709 |