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Intracellular Signal Transduction and Modification of the Tumor Microenvironment Induced by RET/PTCs in Papillary Thyroid Carcinoma

RET gene rearrangements (RET/PTCs) represent together with BRAF point mutations the two major groups of mutations involved in papillary thyroid carcinoma (PTC) initiation and progression. In this review, we will examine the mechanisms involved in RET/PTC-induced thyroid cell transformation. In detai...

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Detalles Bibliográficos
Autores principales: Menicali, Elisa, Moretti, Sonia, Voce, Pasquale, Romagnoli, Serena, Avenia, Nicola, Puxeddu, Efisio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357465/
https://www.ncbi.nlm.nih.gov/pubmed/22661970
http://dx.doi.org/10.3389/fendo.2012.00067