LAMTOR1 depletion induces p53-dependent apoptosis via aberrant lysosomal activation

Lysosomal regulation is a poorly understood mechanism that is central to degradation and recycling processes. Here we report that LAMTOR1 (late endosomal/lysosomal adaptor, MAPK and mTOR activator 1) downregulation affects lysosomal activation, through mechanisms that are not solely due to mTORC1 in...

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Detalles Bibliográficos
Autores principales: Malek, M, Guillaumot, P, Huber, A-L, Lebeau, J, Pétrilli, V, Kfoury, A, Mikaelian, I, Renno, T, Manié, S N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358017/
https://www.ncbi.nlm.nih.gov/pubmed/22513874
http://dx.doi.org/10.1038/cddis.2012.39

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358017/
https://www.ncbi.nlm.nih.gov/pubmed/22513874
http://dx.doi.org/10.1038/cddis.2012.39

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