Twelve Positions in a β-Lactamase That Can Expand Its Substrate Spectrum with a Single Amino Acid Substitution

The continuous evolution of β-lactamases resulting in bacterial resistance to β-lactam antibiotics is a major concern in public health, and yet the underlying molecular basis or the pattern of such evolution is largely unknown. We investigated the mechanics of the substrate fspectrum expansion of th...

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Detalles Bibliográficos
Autores principales: Yi, Hyojeong, Cho, Kwang-Hwi, Cho, Yun Sung, Kim, Karan, Nierman, William C., Kim, Heenam Stanley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358254/
https://www.ncbi.nlm.nih.gov/pubmed/22629423
http://dx.doi.org/10.1371/journal.pone.0037585

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358254/
https://www.ncbi.nlm.nih.gov/pubmed/22629423
http://dx.doi.org/10.1371/journal.pone.0037585

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