Assessment and Implication of Prognostic Imbalance in Randomized Controlled Trials with a Binary Outcome – A Simulation Study

BACKGROUND: Chance imbalance in baseline prognosis of a randomized controlled trial can lead to over or underestimation of treatment effects, particularly in trials with small sample sizes. Our study aimed to (1) evaluate the probability of imbalance in a binary prognostic factor (PF) between two tr...

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Detalles Bibliográficos
Autores principales: Chu, Rong, Walter, Stephen D., Guyatt, Gordon, Devereaux, P. J., Walsh, Michael, Thorlund, Kristian, Thabane, Lehana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358303/
https://www.ncbi.nlm.nih.gov/pubmed/22629322
http://dx.doi.org/10.1371/journal.pone.0036677

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358303/
https://www.ncbi.nlm.nih.gov/pubmed/22629322
http://dx.doi.org/10.1371/journal.pone.0036677

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