HIV-1 reverse transcriptase complex with DNA and nevirapine reveals nonnucleoside inhibition mechanism

Combinations of nucleoside and nonnucleoside inhibitors (NNRTIs) of HIV-1 reverse transcriptase (RT) are widely used in anti-AIDS therapies. Five NNRTIs including nevirapine are clinical drugs; however, the molecular mechanism of inhibition by NNRTIs is not clear. We determined the crystal structure...

Descripción completa

Detalles Bibliográficos
Autores principales: Das, Kalyan, Martinez, Sergio E., Bauman, Joseph D., Arnold, Eddy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359132/
https://www.ncbi.nlm.nih.gov/pubmed/22266819
http://dx.doi.org/10.1038/nsmb.2223

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359132/
https://www.ncbi.nlm.nih.gov/pubmed/22266819
http://dx.doi.org/10.1038/nsmb.2223

Ejemplares similares