Neuronal sensitivity to TDP-43 overexpression is dependent on timing of induction

Ubiquitin-immunoreactive neuronal inclusions composed of TAR DNA binding protein of 43 kDa (TDP-43) are a major pathological feature of frontotemporal lobar degeneration (FTLD-TDP). In vivo studies with TDP-43 knockout mice have suggested that TDP-43 plays a critical, although undefined role in deve...

Descripción completa

Detalles Bibliográficos
Autores principales: Cannon, Ashley, Yang, Baoli, Knight, Joshua, Farnham, Ian M., Zhang, Yongjie, Wuertzer, Charles A., D’Alton, Simon, Lin, Wen-lang, Castanedes-Casey, Monica, Rousseau, Linda, Scott, Brittany, Jurasic, Michael, Howard, John, Yu, Xin, Bailey, Rachel, Sarkisian, Matthew R., Dickson, Dennis W., Petrucelli, Leonard, Lewis, Jada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2012
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359456/
https://www.ncbi.nlm.nih.gov/pubmed/22539017
http://dx.doi.org/10.1007/s00401-012-0979-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359456/
https://www.ncbi.nlm.nih.gov/pubmed/22539017
http://dx.doi.org/10.1007/s00401-012-0979-3

Ejemplares similares