Global Gene Expression Profiling in PPAR-γ Agonist-Treated Kidneys in an Orthologous Rat Model of Human Autosomal Recessive Polycystic Kidney Disease

Kidneys are enlarged by aberrant proliferation of tubule epithelial cells leading to the formation of numerous cysts, nephron loss, and interstitial fibrosis in polycystic kidney disease (PKD). Pioglitazone (PIO), a PPAR-γ agonist, decreased cell proliferation, interstitial fibrosis, and inflammatio...

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Detalles Bibliográficos
Autores principales: Yoshihara, Daisuke, Kugita, Masanori, Yamaguchi, Tamio, Aukema, Harold M., Kurahashi, Hiroki, Morita, Miwa, Hiki, Yoshiyuki, Calvet, James P., Wallace, Darren P., Toyohara, Takafumi, Abe, Takaaki, Nagao, Shizuko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359747/
https://www.ncbi.nlm.nih.gov/pubmed/22666229
http://dx.doi.org/10.1155/2012/695898

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359747/
https://www.ncbi.nlm.nih.gov/pubmed/22666229
http://dx.doi.org/10.1155/2012/695898

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