Mechanical unloading reverses transverse tubule remodelling and normalizes local Ca(2+)-induced Ca(2+)release in a rodent model of heart failure

AIMS: Ca(2+)-induced Ca(2+) release (CICR) is critical for contraction in cardiomyocytes. The transverse (t)-tubule system guarantees the proximity of the triggers for Ca(2+) release [L-type Ca(2+) channel, dihydropyridine receptors (DHPRs)] and the sarcoplasmic reticulum Ca(2+) release channels [ry...

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Detalles Bibliográficos
Autores principales: Ibrahim, Michael, Navaratnarajah, Manoraj, Siedlecka, Urszula, Rao, Christopher, Dias, Priyanthi, Moshkov, Alexey V., Gorelik, Julia, Yacoub, Magdi H., Terracciano, Cesare M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Experimental
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359860/
https://www.ncbi.nlm.nih.gov/pubmed/22467752
http://dx.doi.org/10.1093/eurjhf/hfs038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359860/
https://www.ncbi.nlm.nih.gov/pubmed/22467752
http://dx.doi.org/10.1093/eurjhf/hfs038

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