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Mechanical unloading reverses transverse tubule remodelling and normalizes local Ca(2+)-induced Ca(2+)release in a rodent model of heart failure

AIMS: Ca(2+)-induced Ca(2+) release (CICR) is critical for contraction in cardiomyocytes. The transverse (t)-tubule system guarantees the proximity of the triggers for Ca(2+) release [L-type Ca(2+) channel, dihydropyridine receptors (DHPRs)] and the sarcoplasmic reticulum Ca(2+) release channels [ry...

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Detalles Bibliográficos
Autores principales:	Ibrahim, Michael, Navaratnarajah, Manoraj, Siedlecka, Urszula, Rao, Christopher, Dias, Priyanthi, Moshkov, Alexey V., Gorelik, Julia, Yacoub, Magdi H., Terracciano, Cesare M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Experimental
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359860/ https://www.ncbi.nlm.nih.gov/pubmed/22467752 http://dx.doi.org/10.1093/eurjhf/hfs038

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