Stratification of Wilms tumor by genetic and epigenetic analysis

Somatic defects at five loci, WT1, CTNNB1, WTX, TP53 and the imprinted 11p15 region, are implicated in Wilms tumor, the commonest childhood kidney cancer. In this study we analysed all five loci in 120 Wilms tumors. We identified epigenetic 11p15 abnormalities in 69% of tumors, 37% were H19 epimutat...

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Detalles Bibliográficos
Autores principales: Scott, Richard H., Murray, Anne, Baskcomb, Linda, Turnbull, Clare, Loveday, Chey, Al-Saadi, Reem, Williams, Richard, Breatnach, Fin, Gerrard, Mary, Hale, Juliet, Kohler, Janice, Lapunzina, Pablo, Levitt, Gill A., Picton, Sue, Pizer, Barry, Ronghe, Milind D., Traunecker, Heidi, Williams, Denise, Kelsey, Anna, Vujanic, Gordan M., Sebire, Neil J., Grundy, Paul, Stiller, Charles A., Pritchard-Jones, Kathy, Douglas, Jenny, Rahman, Nazneen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2012
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359888/
https://www.ncbi.nlm.nih.gov/pubmed/22470196

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359888/
https://www.ncbi.nlm.nih.gov/pubmed/22470196

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