Regulating Repression: Roles for the Sir4 N-Terminus in Linker DNA Protection and Stabilization of Epigenetic States

Silent information regulator proteins Sir2, Sir3, and Sir4 form a heterotrimeric complex that represses transcription at subtelomeric regions and homothallic mating type (HM) loci in budding yeast. We have performed a detailed biochemical and genetic analysis of the largest Sir protein, Sir4. The N-...

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Detalles Bibliográficos
Autores principales: Kueng, Stephanie, Tsai-Pflugfelder, Monika, Oppikofer, Mariano, Ferreira, Helder C., Roberts, Emma, Tsai, Chinyen, Roloff, Tim-Christoph, Sack, Ragna, Gasser, Susan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359979/
https://www.ncbi.nlm.nih.gov/pubmed/22654676
http://dx.doi.org/10.1371/journal.pgen.1002727

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359979/
https://www.ncbi.nlm.nih.gov/pubmed/22654676
http://dx.doi.org/10.1371/journal.pgen.1002727

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