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Regulating Repression: Roles for the Sir4 N-Terminus in Linker DNA Protection and Stabilization of Epigenetic States

Silent information regulator proteins Sir2, Sir3, and Sir4 form a heterotrimeric complex that represses transcription at subtelomeric regions and homothallic mating type (HM) loci in budding yeast. We have performed a detailed biochemical and genetic analysis of the largest Sir protein, Sir4. The N-...

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Detalles Bibliográficos
Autores principales:	Kueng, Stephanie, Tsai-Pflugfelder, Monika, Oppikofer, Mariano, Ferreira, Helder C., Roberts, Emma, Tsai, Chinyen, Roloff, Tim-Christoph, Sack, Ragna, Gasser, Susan M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359979/ https://www.ncbi.nlm.nih.gov/pubmed/22654676 http://dx.doi.org/10.1371/journal.pgen.1002727

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