Thermodynamics of Aryl-Dihydroxyphenyl-Thiadiazole Binding to Human Hsp90

The design of specific inhibitors against the Hsp90 chaperone and other enzyme relies on the detailed and correct understanding of both the thermodynamics of inhibitor binding and the structural features of the protein-inhibitor complex. Here we present a detailed thermodynamic study of binding of a...

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Detalles Bibliográficos
Autores principales: Kazlauskas, Egidijus, Petrikaitė, Vilma, Michailovienė, Vilma, Revuckienė, Jurgita, Matulienė, Jurgita, Grinius, Leonas, Matulis, Daumantas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360036/
https://www.ncbi.nlm.nih.gov/pubmed/22655030
http://dx.doi.org/10.1371/journal.pone.0036899

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360036/
https://www.ncbi.nlm.nih.gov/pubmed/22655030
http://dx.doi.org/10.1371/journal.pone.0036899

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