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Thermodynamics of Aryl-Dihydroxyphenyl-Thiadiazole Binding to Human Hsp90
The design of specific inhibitors against the Hsp90 chaperone and other enzyme relies on the detailed and correct understanding of both the thermodynamics of inhibitor binding and the structural features of the protein-inhibitor complex. Here we present a detailed thermodynamic study of binding of a...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360036/ https://www.ncbi.nlm.nih.gov/pubmed/22655030 http://dx.doi.org/10.1371/journal.pone.0036899 |