Loss of CCDC6, the First Identified RET Partner Gene, Affects pH2AX S139 Levels and Accelerates Mitotic Entry upon DNA Damage

CCDC6 was originally identified in chimeric genes caused by chromosomal translocation involving the RET proto-oncogene in some thryoid tumors mostly upon ionizing radiation exposure. Recognised as a pro-apoptotic phosphoprotein that negatively regulates CREB1-dependent transcription, CCDC6 is an ATM...

Descripción completa

Detalles Bibliográficos
Autores principales: Merolla, Francesco, Luise, Chiara, Muller, Mark T., Pacelli, Roberto, Fusco, Alfredo, Celetti, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360053/
https://www.ncbi.nlm.nih.gov/pubmed/22655027
http://dx.doi.org/10.1371/journal.pone.0036177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360053/
https://www.ncbi.nlm.nih.gov/pubmed/22655027
http://dx.doi.org/10.1371/journal.pone.0036177

Ejemplares similares