Nilotinib Counteracts P-Glycoprotein-Mediated Multidrug Resistance and Synergizes the Antitumoral Effect of Doxorubicin in Soft Tissue Sarcomas

The therapeutic effect of doxorubicin (DXR) in the treatment of soft tissue sarcomas (STS) is limited by its toxicity and the development of multidrug resistance (MDR), the latter mainly induced by high expression of efflux pumps (e.g., P-glycoprotein [P-gp]). Therefore, the search for alternative t...

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Detalles Bibliográficos
Autores principales: Villar, Victor Hugo, Vögler, Oliver, Martínez-Serra, Jordi, Ramos, Rafael, Calabuig-Fariñas, Silvia, Gutiérrez, Antonio, Barceló, Francisca, Martín-Broto, Javier, Alemany, Regina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360613/
https://www.ncbi.nlm.nih.gov/pubmed/22662203
http://dx.doi.org/10.1371/journal.pone.0037735

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360613/
https://www.ncbi.nlm.nih.gov/pubmed/22662203
http://dx.doi.org/10.1371/journal.pone.0037735

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