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Hyaluronan Binding Motifs of USP17 and SDS3 Exhibit Anti-Tumor Activity

BACKGROUND: We previously reported that the USP17 deubiquitinating enzyme having hyaluronan binding motifs (HABMs) interacts with human SDS3 (suppressor of defective silencing 3) and specifically deubiquitinates Lys-63 branched polyubiquitination of SDS3 resulting in negative regulation of histone d...

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Detalles Bibliográficos
Autores principales: Ramakrishna, Suresh, Suresh, Bharathi, Bae, Su-Mi, Ahn, Woong-Shick, Lim, Key-Hwan, Baek, Kwang-Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360616/
https://www.ncbi.nlm.nih.gov/pubmed/22662218
http://dx.doi.org/10.1371/journal.pone.0037772