The Arg233Lys AQP0 Mutation Disturbs Aquaporin0-Calmodulin Interaction Causing Polymorphic Congenital Cataract

Calmodulin (CaM) directly interacts with the aquaporin 0 (AQP0) C-terminus in a calcium dependent manner to regulate the water permeability of AQP0. We previously identified a missense mutation (p.R233K) in the putative CaM binding domain of AQP0 C-terminus in a congenital cataract family. This stud...

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Detalles Bibliográficos
Autores principales: Hu, Shanshan, Wang, Binbin, Qi, Yanhua, Lin, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360748/
https://www.ncbi.nlm.nih.gov/pubmed/22662182
http://dx.doi.org/10.1371/journal.pone.0037637

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360748/
https://www.ncbi.nlm.nih.gov/pubmed/22662182
http://dx.doi.org/10.1371/journal.pone.0037637

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