ATP Induced Brain-Derived Neurotrophic Factor Expression and Release from Osteoarthritis Synovial Fibroblasts Is Mediated by Purinergic Receptor P2X4

Brain-derived neurotrophic factor (BDNF), a neuromodulator involved in nociceptive hypersensitivity in the central nervous system, is also expressed in synoviocytes of osteoarthritis (OA) and rheumatoid arthritis (RA) patients. We investigated the role of P2 purinoreceptors in the induction of BDNF...

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Detalles Bibliográficos
Autores principales: Klein, Kerstin, Aeschlimann, André, Jordan, Suzana, Gay, Renate, Gay, Steffen, Sprott, Haiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360754/
https://www.ncbi.nlm.nih.gov/pubmed/22715356
http://dx.doi.org/10.1371/journal.pone.0036693

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360754/
https://www.ncbi.nlm.nih.gov/pubmed/22715356
http://dx.doi.org/10.1371/journal.pone.0036693

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