Hepatitis C Virus Sensitizes Host Cells to TRAIL-Induced Apoptosis by Up-Regulating DR4 and DR5 via a MEK1-Dependent Pathway

BACKGROUND: Hepatitis C virus (HCV) is the leading cause of liver fibrosis, cirrhosis and hepatocellular carcinoma. It is believed that continuous liver cell apoptosis contributes to HCV pathogenesis. Recent studies have shown that HCV infection can sensitize host cells to TNF-related apoptosis-indu...

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Detalles Bibliográficos
Autores principales: Deng, Zhongfan, Yan, Huijuan, Hu, Jiajie, Zhang, Shengwei, Peng, Peng, Liu, Qingzhen, Guo, Deyin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360765/
https://www.ncbi.nlm.nih.gov/pubmed/22662193
http://dx.doi.org/10.1371/journal.pone.0037700

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360765/
https://www.ncbi.nlm.nih.gov/pubmed/22662193
http://dx.doi.org/10.1371/journal.pone.0037700

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