Cargando…

Hepatitis C Virus Sensitizes Host Cells to TRAIL-Induced Apoptosis by Up-Regulating DR4 and DR5 via a MEK1-Dependent Pathway

BACKGROUND: Hepatitis C virus (HCV) is the leading cause of liver fibrosis, cirrhosis and hepatocellular carcinoma. It is believed that continuous liver cell apoptosis contributes to HCV pathogenesis. Recent studies have shown that HCV infection can sensitize host cells to TNF-related apoptosis-indu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Deng, Zhongfan, Yan, Huijuan, Hu, Jiajie, Zhang, Shengwei, Peng, Peng, Liu, Qingzhen, Guo, Deyin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360765/ https://www.ncbi.nlm.nih.gov/pubmed/22662193 http://dx.doi.org/10.1371/journal.pone.0037700

Ejemplares similares

Salirasib sensitizes hepatocarcinoma cells to TRAIL-induced apoptosis through DR5 and survivin-dependent mechanisms
por: Charette, N, et al.
Publicado: (2013)

Thymoquinone Crosstalks with DR5 to Sensitize TRAIL Resistance and Stimulate ROS-Mediated Cancer Apoptosis
por: Abd-Rabou, Ahmed A, et al.
Publicado: (2021)

Rhein promotes TRAIL-induced apoptosis in bladder cancer cells by up-regulating DR5 expression
por: Ma, Liang, et al.
Publicado: (2022)

DR5 Up-Regulation Induced by Dichloroacetate Sensitizes Tumor Cells to Lipid Nanoparticles Decorated with TRAIL
por: Marco-Brualla, Joaquín, et al.
Publicado: (2023)

STAT5 inhibition induces TRAIL/DR4 dependent apoptosis in peripheral T-cell lymphoma
por: Simpson, Haley M., et al.
Publicado: (2018)

Lestaurtinib potentiates TRAIL‐induced apoptosis in glioma via CHOP‐dependent DR5 induction
por: Cao, Yingxiao, et al.
Publicado: (2020)

Dissecting the roles of DR4, DR5 and c-FLIP in the regulation of Geranylgeranyltransferase I inhibition-mediated augmentation of TRAIL-induced apoptosis
por: Chen, Shuzhen, et al.
Publicado: (2010)

Death Receptors DR4 and DR5 Undergo Spontaneous and Ligand-Mediated Endocytosis and Recycling Regardless of the Sensitivity of Cancer Cells to TRAIL
por: Artykov, Artem A., et al.
Publicado: (2021)

Modulation of TRAIL resistance in colon carcinoma cells: Different contributions of DR4 and DR5
por: van Geelen, Caroline MM, et al.
Publicado: (2011)

Inhibition of B-Raf/MEK/ERK signaling suppresses DR5 expression and impairs response of cancer cells to DR5-mediated apoptosis and T cell-induced killing
por: Oh, You-Take, et al.
Publicado: (2015)

Ginsenoside compound K sensitizes human colon cancer cells to TRAIL-induced apoptosis via autophagy-dependent and -independent DR5 upregulation
por: Chen, Lei, et al.
Publicado: (2016)

TRAIL death receptors DR4 and DR5 mediate cerebral microvascular endothelial cell apoptosis induced by oligomeric Alzheimer's Aβ
por: Fossati, S, et al.
Publicado: (2012)

Chloroquine enhances TRAIL-mediated apoptosis through up-regulation of DR5 by stabilization of mRNA and protein in cancer cells
por: Park, Eun Jung, et al.
Publicado: (2016)

FTY720 enhances TRAIL-mediated apoptosis by up-regulating DR5 and down-regulating Mcl-1 in cancer cells
por: Woo, Seon Min, et al.
Publicado: (2015)

Nimesulide, a COX-2 inhibitor, sensitizes pancreatic cancer cells to TRAIL-induced apoptosis by promoting DR5 clustering †
por: Vunnam, Nagamani, et al.
Publicado: (2023)

Paradoxical activation of MEK/ERK signaling induced by B-Raf inhibition enhances DR5 expression and DR5 activation-induced apoptosis in Ras-mutant cancer cells
por: Oh, You-Take, et al.
Publicado: (2016)

Role of Endoplasmic Reticulum Stress in α-TEA Mediated TRAIL/DR5 Death Receptor Dependent Apoptosis
por: Tiwary, Richa, et al.
Publicado: (2010)

Corrigendum: Death Receptors DR4 and DR5 Undergo Spontaneous and Ligand-Mediated Endocytosis and Recycling Regardless of the Sensitivity of Cancer Cells to TRAIL
por: Artykov, Artem A., et al.
Publicado: (2022)

Non-Thermal Plasma Couples Oxidative Stress to TRAIL Sensitization through DR5 Upregulation
por: Hwang, Soon Young, et al.
Publicado: (2020)

Delphinidin sensitizes prostate cancer cells to TRAIL-induced apoptosis, by inducing DR5 and causing caspase-mediated HDAC3 cleavage
por: Ko, Hyeonseok, et al.
Publicado: (2015)

3-Bromopyruvate sensitizes human breast cancer cells to TRAIL-induced apoptosis via the phosphorylated AMPK-mediated upregulation of DR5
por: Chen, Yuzhong, et al.
Publicado: (2018)

Downregulation of c-FLIP and upregulation of DR-5 by cantharidin sensitizes TRAIL-mediated apoptosis in prostate cancer cells via autophagy flux
por: Nazim, Uddin Md, et al.
Publicado: (2020)

3-Bromopyruvate sensitizes human breast cancer cells to TRAIL-induced apoptosis via the phosphorylated AMPK-mediated upregulation of DR5
por: Chen, Yuzhong, et al.
Publicado: (2022)

Combination of TRAIL with Bortezomib Shifted Apoptotic Signaling from DR4 to DR5 Death Receptor by Selective Internalization and Degradation of DR4
por: Bychkov, Maxim L., et al.
Publicado: (2014)

Potentiation of TRAIL-Induced Apoptosis in TRAIL-Resistant Cholangiocarcinoma Cells by Curcumin through the Induction of DR5 Membrane Localization and Disruption of the Anti-Apoptotic Complex DR5/DDX3/GSK3β
por: Visitnonthachai, Daranee, et al.
Publicado: (2023)

TRAIL, DR5 and caspase 3-dependent apoptosis in vessels of diseased human temporomandibular joint disc. An immunohistochemical study
por: Loreto, C., et al.
Publicado: (2010)

Puma and Trail/Dr5 Pathways Control Radiation-Induced Apoptosis in Distinct Populations of Testicular Progenitors
por: Coureuil, Mathieu, et al.
Publicado: (2010)

Artemisinin Derivatives Stimulate DR5-Specific TRAIL-Induced Apoptosis by Regulating Wildtype P53
por: Zhou, Xinyu, et al.
Publicado: (2020)

HTNV Sensitizes Host Toward TRAIL-Mediated Apoptosis—A Pivotal Anti-hantaviral Role of TRAIL
por: Chen, Qing-Zhou, et al.
Publicado: (2020)

Inhibition of IGF-1R-Dependent PI3K Activation Sensitizes Colon Cancer Cells Specifically to DR5-Mediated Apoptosis But Not to rhTRAIL
por: Pennarun, Bodvael, et al.
Publicado: (2010)

Up-regulation of the DR5 Expression by Proteasome Inhibitor MG132 Augments TRAIL-Induced Apoptosis in Soft Tissue Sarcoma Cell Lines
por: Cheong, Hee-Jeong, et al.
Publicado: (2011)

BIX-01294 sensitizes renal cancer Caki cells to TRAIL-induced apoptosis through downregulation of survivin expression and upregulation of DR5 expression
por: Woo, Seon Min, et al.
Publicado: (2018)

Curcumin Sensitizes Kidney Cancer Cells to TRAIL-Induced Apoptosis via ROS Mediated Activation of JNK-CHOP Pathway and Upregulation of DR4
por: Obaidi, Ismael, et al.
Publicado: (2020)

c-Jun NH(2)-terminal kinase-dependent upregulation of DR5 mediates cooperative induction of apoptosis by perifosine and TRAIL
por: Fu, Lei, et al.
Publicado: (2010)

Constitutive localization of DR4 in lipid rafts is mandatory for TRAIL-induced apoptosis in B-cell hematologic malignancies
por: Marconi, M, et al.
Publicado: (2013)

Depletion of CABYR-a/b sensitizes lung cancer cells to TRAIL-induced apoptosis through YAP/p73-mediated DR5 upregulation
por: Xiao, Qianqian, et al.
Publicado: (2016)

RALB GTPase: a critical regulator of DR5 expression and TRAIL sensitivity in KRAS mutant colorectal cancer
por: Khawaja, Hajrah, et al.
Publicado: (2020)

Involvement of Up-Regulation of DR5 Expression and Down-Regulation of c-FLIP in Niclosamide-Mediated TRAIL Sensitization in Human Renal Carcinoma Caki Cells
por: Yun, Jeong Mi, et al.
Publicado: (2018)

Structural basis of LaDR5, a novel agonistic anti-death receptor 5 (DR5) monoclonal antibody, to inhibit DR5/TRAIL complex formation
por: Qiao, Chunxia, et al.
Publicado: (2012)

Targeting AML through DR4 with a novel variant of rhTRAIL
por: Szegezdi, Eva, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_8le4bt2spvvgq96svej9ibnffp