Cargando…

Dopamine Induced Neurodegeneration in a PINK1 Model of Parkinson's Disease

BACKGROUND: Parkinson's disease is a common neurodegenerative disease characterised by progressive loss of dopaminergic neurons, leading to dopamine depletion in the striatum. Mutations in the PINK1 gene cause an autosomal recessive form of Parkinson's disease. Loss of PINK1 function cause...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gandhi, Sonia, Vaarmann, Annika, Yao, Zhi, Duchen, Michael R., Wood, Nicholas W., Abramov, Andrey Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360782/ https://www.ncbi.nlm.nih.gov/pubmed/22662171 http://dx.doi.org/10.1371/journal.pone.0037564

Ejemplares similares

PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-Induced Cell Death
por: Gandhi, Sonia, et al.
Publicado: (2009)

Dopamine protects neurons against glutamate-induced excitotoxicity
por: Vaarmann, A, et al.
Publicado: (2013)

Mechanism of Oxidative Stress in Neurodegeneration
por: Gandhi, Sonia, et al.
Publicado: (2012)

Bioenergetic Consequences of PINK1 Mutations in Parkinson Disease
por: Abramov, Andrey Yurevich, et al.
Publicado: (2011)

PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic Neurons
por: Wood-Kaczmar, Alison, et al.
Publicado: (2008)

Correction: PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic Neurons
por: Wood-Kaczmar, Alison, et al.
Publicado: (2008)

Correction: PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic Neurons
por: Wood-Kaczmar, Alison, et al.
Publicado: (2008)

Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson's disease
por: Celardo, I, et al.
Publicado: (2016)

PINK1 cleavage at position A103 by the mitochondrial protease PARL
por: Deas, Emma, et al.
Publicado: (2011)

PINK1, cancer and neurodegeneration
por: O'Flanagan, Ciara H., et al.
Publicado: (2016)

Loss of PINK1 enhances neurodegeneration in a mouse model of Parkinson's disease triggered by mitochondrial stress()
por: Moisoi, Nicoleta, et al.
Publicado: (2014)

Mitophagy and Parkinson's disease: The PINK1–parkin link()
por: Deas, Emma, et al.
Publicado: (2011)

Mechanism of neurodegeneration of neurons with mitochondrial DNA mutations
por: Abramov, Andrey Y., et al.
Publicado: (2010)

PINK1/PARKIN signalling in neurodegeneration and neuroinflammation
por: Quinn, Peter M. J., et al.
Publicado: (2020)

Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration
por: Gispert, Suzana, et al.
Publicado: (2009)

PINK1 deficiency in β-cells increases basal insulin secretion and improves glucose tolerance in mice
por: Deas, Emma, et al.
Publicado: (2014)

Pink1/Parkin link inflammation, mitochondrial stress, and neurodegeneration
por: Newman, Laura E., et al.
Publicado: (2018)

Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease
por: Deas, Emma, et al.
Publicado: (2016)

Interaction of Mitochondrial Calcium and ROS in Neurodegeneration
por: Baev, Artyom Y., et al.
Publicado: (2022)

Interaction of Oxidative Stress and Misfolded Proteins in the Mechanism of Neurodegeneration
por: Abramov, Andrey Y., et al.
Publicado: (2020)

Outlook of PINK1/Parkin signaling in molecular etiology of Parkinson’s disease, with insights into Pink1 knockout models
por: Wang, Zhangting, et al.
Publicado: (2023)

To be or not to be pink(1): contradictory findings in an animal model for Parkinson’s disease
por: de Haas, Ria, et al.
Publicado: (2019)

Increased cysteine metabolism in PINK1 models of Parkinson's disease
por: Travaglio, Marco, et al.
Publicado: (2023)

Glutathione S-Transferase Alpha 4 Prevents Dopamine Neurodegeneration in a Rat Alpha-Synuclein Model of Parkinson’s Disease
por: Jewett, Michael, et al.
Publicado: (2018)

T313M polymorphism of the PINK1 gene in Parkinson’s disease
por: LUO, QIN, et al.
Publicado: (2014)

Prospects for the Development of Pink1 and Parkin Activators for the Treatment of Parkinson’s Disease
por: Blagov, Alexander V., et al.
Publicado: (2022)

Can Interactions Between α-Synuclein, Dopamine and Calcium Explain Selective Neurodegeneration in Parkinson's Disease?
por: Post, Michael R., et al.
Publicado: (2018)

The Oxidative Pathway to Dopamine–Protein Conjugates and Their Pro-Oxidant Activities: Implications for the Neurodegeneration of Parkinson’s Disease
por: Wakamatsu, Kazumasa, et al.
Publicado: (2019)

The Roles of PINK1 and Parkin in Parkinson's Disease
por: Jones, Rachel
Publicado: (2010)

Enhancing NAD(+) salvage metabolism is neuroprotective in a PINK1 model of Parkinson's disease
por: Lehmann, Susann, et al.
Publicado: (2016)

PINK1 function in health and disease
por: Deas, Emma, et al.
Publicado: (2009)

CRISPR/Cas9-mediated PINK1 deletion leads to neurodegeneration in rhesus monkeys
por: Yang, Weili, et al.
Publicado: (2019)

Impaired mitochondrial homeostasis and neurodegeneration: towards new therapeutic targets?
por: Corona, Juan Carlos, et al.
Publicado: (2014)

PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis
por: Yang, Weili, et al.
Publicado: (2021)

Changes in Tyrosine Hydroxylase Activity and Dopamine Synthesis in the Nigrostriatal System of Mice in an Acute Model of Parkinson’s Disease as a Manifestation of Neurodegeneration and Neuroplasticity
por: Kolacheva, Anna, et al.
Publicado: (2022)

The Bioenergetic Status Relates to Dopamine Neuron Loss in Familial PD with PINK1 Mutations
por: Hilker, Rüediger, et al.
Publicado: (2012)

PKA Phosphorylation of NCLX Reverses Mitochondrial Calcium Overload and Depolarization, Promoting Survival of PINK1-Deficient Dopaminergic Neurons
por: Kostic, Marko, et al.
Publicado: (2015)

Quality control gone wrong: mitochondria, lysosomal storage disorders and neurodegeneration
por: Osellame, L D, et al.
Publicado: (2014)

Structure of PINK1 and mechanisms of Parkinson's disease-associated mutations
por: Kumar, Atul, et al.
Publicado: (2017)

Disruption of Mitochondrial Homeostasis: The Role of PINK1 in Parkinson’s Disease
por: Vizziello, Maria, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_tapv1qpn9nmv8258uq92um7b1e