Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis

Sirt3 is a mitochondrial sirtuin, predominantly expressed in highly metabolic tissues. Germline ablation of Sirt3 has major metabolic consequences, including increased susceptibility to metabolic damage and oxidative stress after high fat feeding. In order to determine the contribution of liver and...

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Detalles Bibliográficos
Autores principales: Fernandez-Marcos, Pablo J., Jeninga, Ellen H., Canto, Carles, Harach, Taoufiq, de Boer, Vincent C. J., Andreux, Penelope, Moullan, Norman, Pirinen, Eija, Yamamoto, Hiroyasu, Houten, Sander M., Schoonjans, Kristina, Auwerx, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361023/
https://www.ncbi.nlm.nih.gov/pubmed/22645641
http://dx.doi.org/10.1038/srep00425

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361023/
https://www.ncbi.nlm.nih.gov/pubmed/22645641
http://dx.doi.org/10.1038/srep00425

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