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Dynamic regulatory on/off minimization for biological systems under internal temporal perturbations

BACKGROUND: Flux balance analysis (FBA) together with its extension, dynamic FBA, have proven instrumental for analyzing the robustness and dynamics of metabolic networks by employing only the stoichiometry of the included reactions coupled with adequately chosen objective function. In addition, und...

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Detalles Bibliográficos
Autores principales: Kleessen, Sabrina, Nikoloski, Zoran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361480/
https://www.ncbi.nlm.nih.gov/pubmed/22409942
http://dx.doi.org/10.1186/1752-0509-6-16