NLRC4-driven interleukin-1β production discriminates between pathogenic and commensal bacteria and promotes host intestinal defense

Intestinal phagocytes transport oral antigens and promote immune tolerance, but their role in innate immune responses remains unclear. Here we report that intestinal phagocytes are anergic to Toll-like receptor ligands or commensals, but constitutively express pro-interleukin-1β (proIL-1β). Upon inf...

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Detalles Bibliográficos
Autores principales: Franchi, Luigi, Kamada, Nobuhiko, Nakamura, Yuumi, Burberry, Aaron, Kuffa, Peter, Suzuki, Shiho, Shaw, Michael H., Kim, Yun-Gi, Núñez, Gabriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361590/
https://www.ncbi.nlm.nih.gov/pubmed/22484733
http://dx.doi.org/10.1038/ni.2263

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361590/
https://www.ncbi.nlm.nih.gov/pubmed/22484733
http://dx.doi.org/10.1038/ni.2263

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